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Mutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domain

Simian virus 40 large T antigen contains an amino terminal J domain that catalyzes T antigen-mediated viral DNA replication and cellular transformation. To dissect the role of the J domain in these processes, we exploited the genetic tools available only in the yeast Saccharomyces cerevisiae to isol...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Fewell, Sheara W., Pipas, James M., Brodsky, Jeffrey L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122309/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11854498/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.042670999
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