Prevalence of Intrathecal Acyclovir Resistant Virus in Herpes Simplex Encephalitis Patients

Herpes simplex encephalitis (HSE) is a life-threatening complication of herpes simplex virus (HSV) infection. Acyclovir (ACV) is the antiviral treatment of choice, but may lead to emergence of ACV-resistant (ACV(R)) HSV due to mutations in the viral UL23 gene encoding for the ACV-targeted thymidine...

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Publicado en:PLoS One
Autores principales: Mitterreiter, Johanna G., Titulaer, Maarten J., van Nierop, Gijsbert P., van Kampen, Jeroen J. A., Aron, Georgina I., Osterhaus, Albert D. M. E., Verjans, Georges M. G. M., Ouwendijk, Werner J. D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865163/
https://ncbi.nlm.nih.gov/pubmed/27171421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155531
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