Validation and Optimization of an Ex Vivo Assay of Intestinal Mucosal Biopsies in Crohn’s Disease: Reflects Inflammation and Drug Effects

Crohn’s disease (CD) is a chronic illness demanding better therapeutics. The marketed biologics only benefit some patients or elicit diminishing effect over time. To complement the known methods in drug development and to obtain patient specific drug responses, we optimized and validated a known hum...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Vadstrup, Kasper, Galsgaard, Elisabeth Douglas, Gerwien, Jens, Vester-Andersen, Marianne Kajbæk, Pedersen, Julie Steen, Rasmussen, Julie, Neermark, Søren, Kiszka-Kanowitz, Marianne, Jensen, Teis, Bendtsen, Flemming
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865152/
https://ncbi.nlm.nih.gov/pubmed/27171179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155335
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