Validation and Optimization of an Ex Vivo Assay of Intestinal Mucosal Biopsies in Crohn’s Disease: Reflects Inflammation and Drug Effects

Crohn’s disease (CD) is a chronic illness demanding better therapeutics. The marketed biologics only benefit some patients or elicit diminishing effect over time. To complement the known methods in drug development and to obtain patient specific drug responses, we optimized and validated a known hum...

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Publicado en:PLoS One
Autores principales: Vadstrup, Kasper, Galsgaard, Elisabeth Douglas, Gerwien, Jens, Vester-Andersen, Marianne Kajbæk, Pedersen, Julie Steen, Rasmussen, Julie, Neermark, Søren, Kiszka-Kanowitz, Marianne, Jensen, Teis, Bendtsen, Flemming
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865152/
https://ncbi.nlm.nih.gov/pubmed/27171179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155335
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