Validation and Optimization of an Ex Vivo Assay of Intestinal Mucosal Biopsies in Crohn’s Disease: Reflects Inflammation and Drug Effects

Crohn’s disease (CD) is a chronic illness demanding better therapeutics. The marketed biologics only benefit some patients or elicit diminishing effect over time. To complement the known methods in drug development and to obtain patient specific drug responses, we optimized and validated a known hum...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Vadstrup, Kasper, Galsgaard, Elisabeth Douglas, Gerwien, Jens, Vester-Andersen, Marianne Kajbæk, Pedersen, Julie Steen, Rasmussen, Julie, Neermark, Søren, Kiszka-Kanowitz, Marianne, Jensen, Teis, Bendtsen, Flemming
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865152/
https://ncbi.nlm.nih.gov/pubmed/27171179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155335
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