Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8(+) T Cells

Interferon Regulatory Factor-8 (IRF8) is constitutively expressed in monocytes and B cell lineages and plays important roles in immunity to pathogens and cancer. Although IRF8 expression is induced in activated T cells, the functional relevance of IRF8 in T cell-mediated immunity is not well underst...

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Udgivet i:PLoS One
Main Authors: Sun, Lin, St. Leger, Anthony J., Yu, Cheng-Rong, He, Chang, Mahdi, Rashid M., Chan, Chi-Chao, Wang, Hongsheng, Morse, Herbert C., Egwuagu, Charles E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865128/
https://ncbi.nlm.nih.gov/pubmed/27171004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155420
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