The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice

Apolipoprotein E4 (ApoE4), one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD). ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of neurodegeneration. Moreover, ApoE protects against h...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Janssen, Carola I. F., Jansen, Diane, Mutsaers, Martina P. C., Dederen, Pieter J. W. C., Geenen, Bram, Mulder, Monique T., Kiliaan, Amanda J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865084/
https://ncbi.nlm.nih.gov/pubmed/27171180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155307
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