A longitudinal study of cognition, proton MR spectroscopy and synaptic and neuronal pathology in aging wild-type and AβPPswe-PS1dE9 mice.

Proton magnetic resonance spectroscopy ((1)H MRS) is a valuable tool in Alzheimer's disease research, investigating the functional integrity of the brain. The present longitudinal study set out to characterize the neurochemical profile of the hippocampus, measured by single voxel (1)H MRS at 7...

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Autori principali: Diane Jansen, Valerio Zerbi, Carola I F Janssen, Pieter J W C Dederen, Martina P C Mutsaers, Anne Hafkemeijer, Anna-Lena Janssen, Cindy L M Nobelen, Andor Veltien, Jack J Asten, Arend Heerschap, Amanda J Kiliaan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2013-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC3661598?pdf=render
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