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Frequent mutations in acetylation and ubiquitination sites suggest novel driver mechanisms of cancer

BACKGROUND: Discovery of cancer drivers is a major goal of cancer research. Driver genes and pathways are often predicted using mutation frequency, assuming that statistically significant recurrence of specific somatic mutations across independent samples indicates their importance in cancer. Howeve...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Narayan, Soumil, Bader, Gary D., Reimand, Jüri
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864925/
https://ncbi.nlm.nih.gov/pubmed/27175787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0311-2
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