PAI‐1, a target gene of miR‐143, regulates invasion and metastasis by upregulating MMP‐13 expression of human osteosarcoma

Despite recent improvements in the therapy for osteosarcoma, 30–40% of osteosarcoma patients die of this disease, mainly due to its lung metastasis. We have previously reported that intravenous injection of miR‐143 significantly suppresses lung metastasis of human osteosarcoma cells (143B) in a mous...

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Vydáno v:Cancer Med
Hlavní autoři: Hirahata, Mio, Osaki, Mitsuhiko, Kanda, Yusuke, Sugimoto, Yui, Yoshioka, Yusuke, Kosaka, Nobuyoshi, Takeshita, Fumitaka, Fujiwara, Tomohiro, Kawai, Akira, Ito, Hisao, Ochiya, Takahiro, Okada, Futoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864819/
https://ncbi.nlm.nih.gov/pubmed/26817521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.651
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