PAI‐1, a target gene of miR‐143, regulates invasion and metastasis by upregulating MMP‐13 expression of human osteosarcoma

Despite recent improvements in the therapy for osteosarcoma, 30–40% of osteosarcoma patients die of this disease, mainly due to its lung metastasis. We have previously reported that intravenous injection of miR‐143 significantly suppresses lung metastasis of human osteosarcoma cells (143B) in a mous...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Hirahata, Mio, Osaki, Mitsuhiko, Kanda, Yusuke, Sugimoto, Yui, Yoshioka, Yusuke, Kosaka, Nobuyoshi, Takeshita, Fumitaka, Fujiwara, Tomohiro, Kawai, Akira, Ito, Hisao, Ochiya, Takahiro, Okada, Futoshi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864819/
https://ncbi.nlm.nih.gov/pubmed/26817521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.651
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