Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae.
Development of multiple drug resistance in tumor cells involves amplification of the mdr1 gene product, a 170-kDa plasma membrane glycoprotein that is an ATP-driven pump that extrudes the drugs. Human mdr1 (also designated as PGY1) cDNA was expressed in yeast cells by using the promoter and translat...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1992
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48645/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1347948/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.6.2302 |
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