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Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae.
Development of multiple drug resistance in tumor cells involves amplification of the mdr1 gene product, a 170-kDa plasma membrane glycoprotein that is an ATP-driven pump that extrudes the drugs. Human mdr1 (also designated as PGY1) cDNA was expressed in yeast cells by using the promoter and translat...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1992
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC48645/ https://ncbi.nlm.nih.gov/pubmed/1347948 |
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