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Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae.

Development of multiple drug resistance in tumor cells involves amplification of the mdr1 gene product, a 170-kDa plasma membrane glycoprotein that is an ATP-driven pump that extrudes the drugs. Human mdr1 (also designated as PGY1) cDNA was expressed in yeast cells by using the promoter and translat...

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Bibliografiska uppgifter
Huvudupphovsmän: Kuchler, K, Thorner, J
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1992
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC48645/
https://ncbi.nlm.nih.gov/pubmed/1347948
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