FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

In hypoxic cells, dysfunctional mitochondria are selectively removed by a specialized autophagic process called mitophagy. The ER–mitochondrial contact site (MAM) is essential for fission of mitochondria prior to engulfment, and the outer mitochondrial membrane protein FUNDC1 interacts with LC3 to r...

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Veröffentlicht in:EMBO J
Hauptverfasser: Wu, Wenxian, Lin, Chunxia, Wu, Keng, Jiang, Lei, Wang, Xiaojing, Li, Wen, Zhuang, Haixia, Zhang, Xingliang, Chen, Hao, Li, Shupeng, Yang, Yue, Lu, Yue, Wang, Jingjing, Zhu, Runzhi, Zhang, Liangqing, Sui, Senfang, Tan, Ning, Zhao, Bin, Zhang, Jingjing, Li, Longxuan, Feng, Du
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864280/
https://ncbi.nlm.nih.gov/pubmed/27145933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593102
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