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ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy
Autophagy eliminates dysfunctional mitochondria in an intricate process known as mitophagy. ULK1 is critical for the induction of autophagy, but its substrate(s) and mechanism of action in mitophagy remain unclear. Here, we show that ULK1 is upregulated and translocates to fragmented mitochondria up...
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| Главные авторы: | , , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BlackWell Publishing Ltd
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210082/ https://ncbi.nlm.nih.gov/pubmed/24671035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201438501 |
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