ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

Autophagy eliminates dysfunctional mitochondria in an intricate process known as mitophagy. ULK1 is critical for the induction of autophagy, but its substrate(s) and mechanism of action in mitophagy remain unclear. Here, we show that ULK1 is upregulated and translocates to fragmented mitochondria up...

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Hlavní autoři: Wu, Wenxian, Tian, Weili, Hu, Zhe, Chen, Guo, Huang, Lei, Li, Wen, Zhang, Xingli, Xue, Peng, Zhou, Changqian, Liu, Lei, Zhu, Yushan, Zhang, Xingliang, Li, Longxuan, Zhang, Liangqing, Sui, Senfang, Zhao, Bin, Feng, Du
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Scientific Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210082/
https://ncbi.nlm.nih.gov/pubmed/24671035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201438501
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