Absence of UCHL 1 function leads to selective motor neuropathy

OBJECTIVE: The aim of this study was to investigate the role of ubiquitin C‐terminal hydrolase‐L1 (UCHL1) for motor neuron circuitry and especially in spinal motor neuron (SMN) health, function, and connectivity. METHODS: Since mutations in UCHL1 gene leads to motor dysfunction in patients, we inves...

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: Genç, Barış, Jara, Javier H., Schultz, Megan C., Manuel, Marin, Stanford, Macdonell J., Gautam, Mukesh, Klessner, Jodi L., Sekerkova, Gabriella, Heller, Daniel B., Cox, Gregory A., Heckman, Charles J., DiDonato, Christine J., Özdinler, P. Hande
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863746/
https://ncbi.nlm.nih.gov/pubmed/27231703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.298
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