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Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms
Mutations in the ALS2 gene result in early-onset amyotrophic lateral sclerosis, infantile-onset ascending hereditary spastic paraplegia and juvenile primary lateral sclerosis, suggesting prominent upper motor neuron involvement. However, the importance of alsin function for corticospinal motor neuro...
Gespeichert in:
| Veröffentlicht in: | Hum Mol Genet |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4764190/ https://ncbi.nlm.nih.gov/pubmed/26755825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv631 |
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