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A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1

3′-untranslated regions (UTRs) specify post-transcriptional fates of mammalian messenger RNAs (mRNAs), yet knowledge of the underlying sequences and mechanisms is largely incomplete. Here, we identify two related novel 3′ UTR motifs in mammals that specify transcript degradation. These motifs are in...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Geissler, Rene, Simkin, Alfred, Floss, Doreen, Patel, Ravi, Fogarty, Elizabeth A., Scheller, Jürgen, Grimson, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863738/
https://ncbi.nlm.nih.gov/pubmed/27151978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.277392.116
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