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A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1

3′-untranslated regions (UTRs) specify post-transcriptional fates of mammalian messenger RNAs (mRNAs), yet knowledge of the underlying sequences and mechanisms is largely incomplete. Here, we identify two related novel 3′ UTR motifs in mammals that specify transcript degradation. These motifs are in...

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Vydáno v:Genes Dev
Hlavní autoři: Geissler, Rene, Simkin, Alfred, Floss, Doreen, Patel, Ravi, Fogarty, Elizabeth A., Scheller, Jürgen, Grimson, Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863738/
https://ncbi.nlm.nih.gov/pubmed/27151978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.277392.116
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