Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyruvate kinase (PK), and PKM2 expression is closely linked to embryogenesis, tissue regeneration, and cancer. To interrogate the functional requirement for PKM2 during development and tissue homeostasis, we generat...

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Vydáno v:Genes Dev
Hlavní autoři: Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn M., Israelsen, William J., Bhutkar, Arjun, Clish, Clary B., Davidson, Shawn M., Luengo, Alba, Bronson, Roderick T., Jacks, Tyler, Vander Heiden, Matthew G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863734/
https://ncbi.nlm.nih.gov/pubmed/27125672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.278549.116
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