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Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine‐mediated immune protection

Influenza vaccination does not provide 100% protection from infection, partly due to antigenic drift of the haemagglutinin (HA) protein. Low serum antibody titres increase the risk of infection. To determine whether there were additional correlates of risk, we examined the relationship between human...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Immunology
Hauptverfasser: DeDiego, Marta L., Anderson, Christopher S., Yang, Hongmei, Holden‐Wiltse, Jeanne, Fitzgerald, Theresa, Treanor, John. J., Topham, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863573/
https://ncbi.nlm.nih.gov/pubmed/26854888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12594
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