Biallelic BRCA2 Mutations Shape the Somatic Mutational Landscape of Aggressive Prostate Tumors

To identify clinically important molecular subtypes of prostate cancer (PCa), we characterized the somatic landscape of aggressive tumors via deep, whole-genome sequencing. In our discovery set of ten tumor/normal subject pairs with Gleason scores of 8–10 at diagnosis, coordinated analysis of germli...

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Bibliographic Details
Published in:Am J Hum Genet
Main Authors: Decker, Brennan, Karyadi, Danielle M., Davis, Brian W., Karlins, Eric, Tillmans, Lori S., Stanford, Janet L., Thibodeau, Stephen N., Ostrander, Elaine A.
Format: Artigo
Language:Inglês
Published: Elsevier 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863563/
https://ncbi.nlm.nih.gov/pubmed/27087322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2016.03.003
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