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Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer

Studies of families who segregate BRCA2 mutations have found that men who carry disease-associated mutations have an increased risk of prostate cancer, particularly early-onset disease. A study of sporadic prostate cancer in the UK reported a prevalence of 2.3% for protein-truncating BRCA2 mutations...

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Detalhes bibliográficos
Main Authors: Agalliu, I, Karlins, E, Kwon, E M, Iwasaki, L M, Diamond, A, Ostrander, E A, Stanford, J L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360390/
https://ncbi.nlm.nih.gov/pubmed/17700570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603929
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