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A quantitative way to estimate clinical off-target effects for human membrane brain targets in CNS research and development
Although many preclinical programs in central nervous system research and development intend to develop highly selective and potent molecules directed at the primary target, they often act upon other off-target receptors. The simple rule of taking the ratios of affinities for the candidate drug at t...
Guardat en:
| Publicat a: | J Exp Pharmacol |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Dove Medical Press
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4863548/ https://ncbi.nlm.nih.gov/pubmed/27186116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JEP.S30808 |
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