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IL-17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis

BACKGROUND: Interleukin-17A (IL-17A) plays a pathogenic role in several rheumatic diseases including spondyloarthritis and, paradoxically, has been described to both promote and protect from bone formation. We therefore examined the effects of IL-17A on osteoblast differentiation in vitro and on per...

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Bibliographic Details
Published in:Arthritis Res Ther
Main Authors: Shaw, Anita T., Maeda, Yukiko, Gravallese, Ellen M.
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863346/
https://ncbi.nlm.nih.gov/pubmed/27165410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0998-x
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