Comparison of the effects of the oral anticancer platinum(IV) complexes oxoplatin and metabolite cis-diammine-tetrachlorido-platinum(IV) on global gene expression of NCI-H526 cells

Platinum(IV) coordination complexes like oxoplatin (cis,cis,trans-diammine-dichlorido-dihydroxido-platinum[IV]) show high stability and therefore can be utilized orally for outpatient care. Although oxoplatin is capable of binding directly to DNA after prolonged incubation, platinum(IV) agents are c...

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Veröffentlicht in:J Exp Pharmacol
Hauptverfasser: Olszewski, Ulrike, Ulsperger, Ernst, Geissler, Klaus, Hamilton, Gerhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2011
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863305/
https://ncbi.nlm.nih.gov/pubmed/27186109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JEP.S13630
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