LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation

B-cell receptor (BCR) signaling plays a critical role in B-cell activation and humoral immunity. In this study, we discovered a critical function of leucine-rich repeat kinase 1 (LRRK1) in BCR-mediated immune responses. Lrrk1(−/−) mice exhibited altered B1a-cell development and basal immunoglobulin...

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Udgivet i:Sci Rep
Main Authors: Morimoto, Keiko, Baba, Yoshihiro, Shinohara, Hisaaki, Kang, Sujin, Nojima, Satoshi, Kimura, Tetsuya, Ito, Daisuke, Yoshida, Yuji, Maeda, Yohei, Sarashina-Kida, Hana, Nishide, Masayuki, Hosokawa, Takashi, Kato, Yasuhiro, Hayama, Yoshitomo, Kinehara, Yuhei, Okuno, Tatsusada, Takamatsu, Hyota, Hirano, Toru, Shima, Yoshihito, Narazaki, Masashi, Kurosaki, Tomohiro, Toyofuku, Toshihiko, Kumanogoh, Atsushi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863158/
https://ncbi.nlm.nih.gov/pubmed/27166870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25738
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