Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus

OBJECTIVE: Despite the importance of type I interferon (IFN-I) in systemic lupus erythematosus (SLE) pathogenesis, the mechanisms of IFN-I production have not been fully elucidated. Recognition of nucleic acids by DNA sensors induces IFN-I and interferon-stimulated genes (ISGs), but the involvement...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Kato, Yasuhiro, Park, JeongHoon, Takamatsu, Hyota, Konaka, Hachirou, Aoki, Wataru, Aburaya, Syunsuke, Ueda, Mitsuyoshi, Nishide, Masayuki, Koyama, Shohei, Hayama, Yoshitomo, Kinehara, Yuhei, Hirano, Toru, Shima, Yoshihito, Narazaki, Masashi, Kumanogoh, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161667/
https://ncbi.nlm.nih.gov/pubmed/29945921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-212988
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