The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

Lysosomes are involved in nutrient sensing via the mechanistic target of rapamycin complex 1 (mTORC1). mTORC1 is tethered to lysosomes by the Ragulator complex, a heteropentamer in which Lamtor1 wraps around Lamtor2–5. Although the Ragulator complex is required for cell migration, the mechanisms by...

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發表在:Nat Commun
Main Authors: Nakatani, Takeshi, Tsujimoto, Kohei, Park, JeongHoon, Jo, Tatsunori, Kimura, Tetsuya, Hayama, Yoshitomo, Konaka, Hachiro, Morita, Takayoshi, Kato, Yasuhiro, Nishide, Masayuki, Koyama, Shyohei, Nada, Shigeyuki, Okada, Masato, Takamatsu, Hyota, Kumanogoh, Atsushi
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184920/
https://ncbi.nlm.nih.gov/pubmed/34099704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23654-3
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