Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting

Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance would be reduced by chemically induced physiologi...

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Foilsithe in:eLife
Main Authors: Mavor, David, Barlow, Kyle, Thompson, Samuel, Barad, Benjamin A, Bonny, Alain R, Cario, Clinton L, Gaskins, Garrett, Liu, Zairan, Deming, Laura, Axen, Seth D, Caceres, Elena, Chen, Weilin, Cuesta, Adolfo, Gate, Rachel E, Green, Evan M, Hulce, Kaitlin R, Ji, Weiyue, Kenner, Lillian R, Mensa, Bruk, Morinishi, Leanna S, Moss, Steven M, Mravic, Marco, Muir, Ryan K, Niekamp, Stefan, Nnadi, Chimno I, Palovcak, Eugene, Poss, Erin M, Ross, Tyler D, Salcedo, Eugenia C, See, Stephanie K, Subramaniam, Meena, Wong, Allison W, Li, Jennifer, Thorn, Kurt S, Conchúir, Shane Ó, Roscoe, Benjamin P, Chow, Eric D, DeRisi, Joseph L, Kortemme, Tanja, Bolon, Daniel N, Fraser, James S
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2016
Ábhair:
Computational and Systems Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862753/
https://ncbi.nlm.nih.gov/pubmed/27111525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15802
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