Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting

Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance would be reduced by chemically induced physiologi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Mavor, David, Barlow, Kyle, Thompson, Samuel, Barad, Benjamin A, Bonny, Alain R, Cario, Clinton L, Gaskins, Garrett, Liu, Zairan, Deming, Laura, Axen, Seth D, Caceres, Elena, Chen, Weilin, Cuesta, Adolfo, Gate, Rachel E, Green, Evan M, Hulce, Kaitlin R, Ji, Weiyue, Kenner, Lillian R, Mensa, Bruk, Morinishi, Leanna S, Moss, Steven M, Mravic, Marco, Muir, Ryan K, Niekamp, Stefan, Nnadi, Chimno I, Palovcak, Eugene, Poss, Erin M, Ross, Tyler D, Salcedo, Eugenia C, See, Stephanie K, Subramaniam, Meena, Wong, Allison W, Li, Jennifer, Thorn, Kurt S, Conchúir, Shane Ó, Roscoe, Benjamin P, Chow, Eric D, DeRisi, Joseph L, Kortemme, Tanja, Bolon, Daniel N, Fraser, James S
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Computational and Systems Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862753/
https://ncbi.nlm.nih.gov/pubmed/27111525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15802
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