Multiscale Model of Mycobacterium tuberculosis Infection Maps Metabolite and Gene Perturbations to Granuloma Sterilization Predictions

Granulomas are a hallmark of tuberculosis. Inside granulomas, the pathogen Mycobacterium tuberculosis may enter a metabolically inactive state that is less susceptible to antibiotics. Understanding M. tuberculosis metabolism within granulomas could contribute to reducing the lengthy treatment requir...

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Détails bibliographiques
Publié dans:Infect Immun
Auteurs principaux: Pienaar, Elsje, Matern, William M., Linderman, Jennifer J., Bader, Joel S., Kirschner, Denise E.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Bacterial Infections
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862722/
https://ncbi.nlm.nih.gov/pubmed/26975995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01438-15
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