STAT6 Signaling Attenuates Interleukin-17-Producing γδ T Cells during Acute Klebsiella pneumoniae Infection

γδ T cells are prevalent at mucosal and epithelial surfaces and are a critical first line of defense against bacterial and fungal pathogens. γδ17 cells are a subset of γδ T cells which, in the presence of IL-23 and IL-1β, produce large quantities of interleukin-17A (IL-17A), a cytokine crucial to th...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Bloodworth, Melissa H., Newcomb, Dawn C., Dulek, Daniel E., Stier, Matthew T., Cephus, Jacqueline Y., Zhang, Jian, Goleniewska, Kasia, Kolls, Jay K., Peebles, R. Stokes
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Host Response and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862712/
https://ncbi.nlm.nih.gov/pubmed/26953325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00646-15
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