Profoundly Reduced CD1c(+) Myeloid Dendritic Cell HLA-DR and CD86 Expression and Increased Tumor Necrosis Factor Production in Experimental Human Blood-Stage Malaria Infection

Dendritic cells (DCs) are sentinels of the immune system that uniquely prime naive cells and initiate adaptive immune responses. CD1c (BDCA-1) myeloid DCs (CD1c(+) mDCs) highly express HLA-DR, have a broad Toll-like receptor (TLR) repertoire, and secrete immune modulatory cytokines. To better unders...

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Detalles Bibliográficos
Publicado en:Infect Immun
Main Authors: Loughland, Jessica R., Minigo, Gabriela, Burel, Julie, Tipping, Peta E., Piera, Kim A., Amante, Fiona H., Engwerda, Christian R., Good, Michael F., Doolan, Denise L., Anstey, Nicholas M., McCarthy, James S., Woodberry, Tonia
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2016
Assuntos:
Host Response and Inflammation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862702/
https://ncbi.nlm.nih.gov/pubmed/26902728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01522-15
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