Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

ALS-8112 is the parent molecule of ALS-8176, a first-in-class nucleoside analog prodrug effective in the clinic against respiratory syncytial virus (RSV) infection. The antiviral activity of ALS-8112 is mediated by its 5'-triphosphate metabolite (ALS-8112-TP, or 2'F-4'ClCH(2)-cytidine...

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Udgivet i:PLoS One
Main Authors: Deval, Jerome, Fung, Amy, Stevens, Sarah K., Jordan, Paul C., Gromova, Tatiana, Taylor, Joshua S., Hong, Jin, Meng, Jia, Wang, Guangyi, Dyatkina, Natalia, Prhavc, Marija, Symons, Julian A., Beigelman, Leo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862670/
https://ncbi.nlm.nih.gov/pubmed/27163448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154097
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