Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2′-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases

Norovirus (NoV) is a positive-sense single-stranded RNA virus that causes acute gastroenteritis and is responsible for 200,000 deaths per year worldwide. No effective vaccine or treatment is available. Recent studies have shown that the nucleoside analogs favipiravir (T-705) and 2′-C-methyl-cytidine...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Jin, Zhinan, Tucker, Kathryn, Lin, Xiaoyan, Kao, C. Cheng, Shaw, Ken, Tan, Hua, Symons, Julian, Behera, Ishani, Rajwanshi, Vivek K., Dyatkina, Natalia, Wang, Guangyi, Beigelman, Leo, Deval, Jerome
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649231/
https://ncbi.nlm.nih.gov/pubmed/26392512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01391-15
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