Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2′-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases

Norovirus (NoV) is a positive-sense single-stranded RNA virus that causes acute gastroenteritis and is responsible for 200,000 deaths per year worldwide. No effective vaccine or treatment is available. Recent studies have shown that the nucleoside analogs favipiravir (T-705) and 2′-C-methyl-cytidine...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Jin, Zhinan, Tucker, Kathryn, Lin, Xiaoyan, Kao, C. Cheng, Shaw, Ken, Tan, Hua, Symons, Julian, Behera, Ishani, Rajwanshi, Vivek K., Dyatkina, Natalia, Wang, Guangyi, Beigelman, Leo, Deval, Jerome
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649231/
https://ncbi.nlm.nih.gov/pubmed/26392512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01391-15
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