Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue

Central nervous system myelin is a multilayered membrane sheath generated by oligodendrocytes for rapid impulse propagation. However, the underlying mechanisms of myelin wrapping have remained unclear. Using an integrative approach of live imaging, electron microscopy and genetics, we show that new...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Snaidero, Nicolas, Möbius, Wiebke, Czopka, Tim, Hekking, Liesbeth H.P., Mathisen, Cliff, Verkleij, Dick, Goebbels, Sandra, Edgar, Julia, Merkler, Doron, Lyons, David A., Nave, Klaus-Armin, Simons, Mikael
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862569/
https://ncbi.nlm.nih.gov/pubmed/24439382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.044
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