Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue

Central nervous system myelin is a multilayered membrane sheath generated by oligodendrocytes for rapid impulse propagation. However, the underlying mechanisms of myelin wrapping have remained unclear. Using an integrative approach of live imaging, electron microscopy and genetics, we show that new...

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Bibliografische gegevens
Gepubliceerd in:Cell
Hoofdauteurs: Snaidero, Nicolas, Möbius, Wiebke, Czopka, Tim, Hekking, Liesbeth H.P., Mathisen, Cliff, Verkleij, Dick, Goebbels, Sandra, Edgar, Julia, Merkler, Doron, Lyons, David A., Nave, Klaus-Armin, Simons, Mikael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862569/
https://ncbi.nlm.nih.gov/pubmed/24439382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.044
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