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Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

The interindividual and intraindividual variabilities in daptomycin pharmacokinetics were investigated in 23 patients (69 pharmacokinetic profiles) who were treated for several months for bone and joint infections. Population daptomycin clearance was significantly influenced by renal function and wa...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Goutelle, Sylvain, Roux, Sandrine, Gagnieu, Marie-Claude, Valour, Florent, Lustig, Sébastien, Ader, Florence, Laurent, Frédéric, Chidiac, Christian, Ferry, Tristan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862545/
https://ncbi.nlm.nih.gov/pubmed/26902764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02597-15
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