Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

The interindividual and intraindividual variabilities in daptomycin pharmacokinetics were investigated in 23 patients (69 pharmacokinetic profiles) who were treated for several months for bone and joint infections. Population daptomycin clearance was significantly influenced by renal function and wa...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Goutelle, Sylvain, Roux, Sandrine, Gagnieu, Marie-Claude, Valour, Florent, Lustig, Sébastien, Ader, Florence, Laurent, Frédéric, Chidiac, Christian, Ferry, Tristan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862545/
https://ncbi.nlm.nih.gov/pubmed/26902764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02597-15
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