Successful Therapy of Murine Visceral Leishmaniasis with Astrakurkurone, a Triterpene Isolated from the Mushroom Astraeus hygrometricus, Involves the Induction of Protective Cell-Mediated Immunity and TLR9

In our previous report, we showed that astrakurkurone, a triterpene isolated from the Indian mushroom Astraeus hygrometricus (Pers.) Morgan, induced reactive oxygen species, leading to apoptosis in Leishmania donovani promastigotes, and also was effective in inhibiting intracellular amastigotes at t...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Mallick, Suvadip, Dutta, Aritri, Chaudhuri, Ankur, Mukherjee, Debasri, Dey, Somaditya, Halder, Subhadra, Ghosh, Joydip, Mukherjee, Debarati, Sultana, Sirin Salma, Biswas, Gunjan, Lai, Tapan Kumar, Patra, Pradyumna, Sarkar, Indranil, Chakraborty, Sibani, Saha, Bhaskar, Acharya, Krishnendu, Pal, Chiranjib
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862535/
https://ncbi.nlm.nih.gov/pubmed/26883702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01943-15
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