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A First-in-Human Study To Assess the Safety and Pharmacokinetics of Monoclonal Antibodies against Human Cytomegalovirus in Healthy Volunteers

Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients and treatment options are limited by toxicities. CSJ148 is a combination of two anti-HCMV human monoclonal antibodies (LJP538 and LJP539) that bind to and inhibit the function of viral HCMV glycoprotein B (gB) a...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Dole, Kiran, Segal, Florencia Pereyra, Feire, Adam, Magnusson, Baldur, Rondon, Juan C., Vemula, Janardhana, Yu, Jing, Pang, Yinuo, Pertel, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862512/
https://ncbi.nlm.nih.gov/pubmed/26926639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02698-15
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