Pharmacokinetics and Concentration-Dependent Efficacy of Isavuconazole for Treatment of Experimental Invasive Pulmonary Aspergillosis

We studied the pharmacokinetics and efficacy of the broad-spectrum triazole isavuconazole for the treatment of experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits. Treatment started 24 h after endotracheal administration of Aspergillus fumigatus inoculum; study su...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Petraitis, Vidmantas, Petraitiene, Ruta, Moradi, Patriss W., Strauss, Gittel E., Katragkou, Aspasia, Kovanda, Laura L., Hope, William W., Walsh, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862472/
https://ncbi.nlm.nih.gov/pubmed/26883703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02665-15
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