Hypomethylation of TET2 Target Genes Identifies a Curable Subset of Acute Myeloid Leukemia

BACKGROUND: Acute myeloid leukemia (AML) is curable in a subset of cases. The DNA methylation regulator TET2 is frequently mutated in AML, and we hypothesized that studying TET2-specific differentially methylated CpGs (tet2-DMCs) improves AML classification. METHODS: We used bisulfite pyrosequencing...

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Gepubliceerd in:J Natl Cancer Inst
Hoofdauteurs: Yamazaki, Jumpei, Taby, Rodolphe, Jelinek, Jaroslav, Raynal, Noel J. M., Cesaroni, Matteo, Pierce, Sherry A., Kornblau, Steven M., Bueso-Ramos, Carlos E., Ravandi, Farhad, Kantarjian, Hagop M., Issa, Jean-Pierre J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862435/
https://ncbi.nlm.nih.gov/pubmed/26568194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv323
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