Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma: A Report of the Children’s Oncology Group DIPG Preclinical Consortium

Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNAseq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor pano...

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Published in:Nat Med
Main Authors: Grasso, Catherine S., Tang, Yujie, Truffaux, Nathalene, Berlow, Noah E., Liu, Lining, Debily, Marie-Anne, Quist, Michael J., Davis, Lara E., Huang, Elaine C., Woo, Pamelyn J, Ponnuswami, Anitha, Chen, Spenser, Johung, Tessa B., Sun, Wenchao, Kogiso, Mari, Du, Yuchen, Lin, Qi, Huang, Yulun, Hütt-Cabezas, Marianne, Warren, Katherine E., Dret, Ludivine Le, Meltzer, Paul S., Mao, Hua, Quezado, Martha, van Vuurden, Dannis G., Abraham, Jinu, Fouladi, Maryam, Svalina, Matthew N., Wang, Nicholas, Hawkins, Cynthia, Nazarian, Javad, Alonso, Marta M., Raabe, Eric, Hulleman, Esther, Spellman, Paul T., Li, Xiao-Nan, Keller, Charles, Pal, Ranadip, Grill, Jacques, Monje, Michelle
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862411/
https://ncbi.nlm.nih.gov/pubmed/25939062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3855
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