Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma: A Report of the Children’s Oncology Group DIPG Preclinical Consortium

Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNAseq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor pano...

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Опубликовано в: :Nat Med
Главные авторы: Grasso, Catherine S., Tang, Yujie, Truffaux, Nathalene, Berlow, Noah E., Liu, Lining, Debily, Marie-Anne, Quist, Michael J., Davis, Lara E., Huang, Elaine C., Woo, Pamelyn J, Ponnuswami, Anitha, Chen, Spenser, Johung, Tessa B., Sun, Wenchao, Kogiso, Mari, Du, Yuchen, Lin, Qi, Huang, Yulun, Hütt-Cabezas, Marianne, Warren, Katherine E., Dret, Ludivine Le, Meltzer, Paul S., Mao, Hua, Quezado, Martha, van Vuurden, Dannis G., Abraham, Jinu, Fouladi, Maryam, Svalina, Matthew N., Wang, Nicholas, Hawkins, Cynthia, Nazarian, Javad, Alonso, Marta M., Raabe, Eric, Hulleman, Esther, Spellman, Paul T., Li, Xiao-Nan, Keller, Charles, Pal, Ranadip, Grill, Jacques, Monje, Michelle
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862411/
https://ncbi.nlm.nih.gov/pubmed/25939062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3855
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