Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma: A Report of the Children’s Oncology Group DIPG Preclinical Consortium

Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNAseq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor pano...

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izdano v:Nat Med
Main Authors: Grasso, Catherine S., Tang, Yujie, Truffaux, Nathalene, Berlow, Noah E., Liu, Lining, Debily, Marie-Anne, Quist, Michael J., Davis, Lara E., Huang, Elaine C., Woo, Pamelyn J, Ponnuswami, Anitha, Chen, Spenser, Johung, Tessa B., Sun, Wenchao, Kogiso, Mari, Du, Yuchen, Lin, Qi, Huang, Yulun, Hütt-Cabezas, Marianne, Warren, Katherine E., Dret, Ludivine Le, Meltzer, Paul S., Mao, Hua, Quezado, Martha, van Vuurden, Dannis G., Abraham, Jinu, Fouladi, Maryam, Svalina, Matthew N., Wang, Nicholas, Hawkins, Cynthia, Nazarian, Javad, Alonso, Marta M., Raabe, Eric, Hulleman, Esther, Spellman, Paul T., Li, Xiao-Nan, Keller, Charles, Pal, Ranadip, Grill, Jacques, Monje, Michelle
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862411/
https://ncbi.nlm.nih.gov/pubmed/25939062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3855
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