Hot spots of DNA double-strand breaks in human rDNA units are produced in vivo

Endogenous hot spots of DNA double-strand breaks (DSBs) are tightly linked with transcription patterns and cancer genomics(1,2). There are nine hot spots of DSBs located in human rDNA units(3–6). Here we describe that the profiles of these hot spots coincide with the profiles of γ-H2AX or H2AX, stro...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tchurikov, Nickolai A., Yudkin, Dmitry V., Gorbacheva, Maria A., Kulemzina, Anastasia I., Grischenko, Irina V., Fedoseeva, Daria M., Sosin, Dmitri V., Kravatsky, Yuri V., Kretova, Olga V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861929/
https://ncbi.nlm.nih.gov/pubmed/27160357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25866
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