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Small-Molecule Binding Aptamers: Selection Strategies, Characterization, and Applications

Aptamers are single-stranded, synthetic oligonucleotides that fold into 3-dimensional shapes capable of binding non-covalently with high affinity and specificity to a target molecule. They are generated via an in vitro process known as the Systematic Evolution of Ligands by EXponential enrichment, f...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Ruscito, Annamaria, DeRosa, Maria C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861895/
https://ncbi.nlm.nih.gov/pubmed/27242994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2016.00014
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