Mutation of Serine 32 to Threonine in Peroxiredoxin 6 Preserves Its Structure and Enzymatic Function but Abolishes Its Trafficking to Lamellar Bodies

Peroxiredoxin 6 (Prdx6), a bifunctional protein with phospholipase A(2) (aiPLA(2)) and GSH peroxidase activities, protects lungs from oxidative stress and participates in lung surfactant phospholipid turnover. Prdx6 has been localized to both cytosol and lamellar bodies (LB) in lung epithelium, and...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Sorokina, Elena M., Dodia, Chandra, Zhou, Suiping, Tao, Jian-Qin, Gao, Ling, Raabe, Tobias, Feinstein, Sheldon I., Fisher, Aron B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861491/
https://ncbi.nlm.nih.gov/pubmed/26921317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698894
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