Mutation of Serine 32 to Threonine in Peroxiredoxin 6 Preserves Its Structure and Enzymatic Function but Abolishes Its Trafficking to Lamellar Bodies

Peroxiredoxin 6 (Prdx6), a bifunctional protein with phospholipase A(2) (aiPLA(2)) and GSH peroxidase activities, protects lungs from oxidative stress and participates in lung surfactant phospholipid turnover. Prdx6 has been localized to both cytosol and lamellar bodies (LB) in lung epithelium, and...

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Vydáno v:J Biol Chem
Hlavní autoři: Sorokina, Elena M., Dodia, Chandra, Zhou, Suiping, Tao, Jian-Qin, Gao, Ling, Raabe, Tobias, Feinstein, Sheldon I., Fisher, Aron B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861491/
https://ncbi.nlm.nih.gov/pubmed/26921317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698894
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