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The Different Conformational States of Tissue Transglutaminase Have Opposing Affects on Cell Viability

Tissue transglutaminase (tTG) is an acyltransferase/GTP-binding protein that contributes to the development of various diseases. In human cancer cells, tTG activates signaling pathways that promote cell growth and survival, whereas in other disorders (i.e. neurodegeneration), overexpression of tTG e...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Singh, Garima, Zhang, Jingwen, Ma, Yilun, Cerione, Richard A., Antonyak, Marc A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861479/
https://ncbi.nlm.nih.gov/pubmed/26893378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.699108
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