Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin-sensitive Genes

FoxO1 binds to insulin response elements located in the promoters of insulin-like growth factor-binding protein 1 (IGFBP1) and glucose-6-phosphatase (G6Pase), activating their expression. Insulin-mediated phosphorylation of FoxO1 promotes cytoplasmic translocation, inhibiting FoxO1-mediated transact...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Yalley, Akua, Schill, Daniel, Hatta, Mitsutoki, Johnson, Nicole, Cirillo, Lisa Ann
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861452/
https://ncbi.nlm.nih.gov/pubmed/26929406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677583
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