Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases

Tumor-associated macrophages (TAM) play pivotal roles in cancer initiation and progression. Monocytes, the precursors of TAMs, normally undergo spontaneous apoptosis within 2 days, but can subsist in the inflammatory tumor microenvironment for continuous survival and generation of sufficient TAMs. T...

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Vydáno v:J Biol Chem
Hlavní autoři: Song, Xiao, Ding, Yanping, Liu, Gang, Yang, Xiao, Zhao, Ruifang, Zhang, Yinlong, Zhao, Xiao, Anderson, Gregory J., Nie, Guangjun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861419/
https://ncbi.nlm.nih.gov/pubmed/26895960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.716316
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